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What is Baclofen?
Baclofen is a muscle relaxant, which has a powerful impact on the nervous system. It is also used to eliminate depression and relieve moderate pain and spasms. Baclofen relieves spinal cord muscles. The drug also reduces muscles tone, increasing amplitude of joint movements. Baclofen has no impact on neuromuscular transmission.
You need to have a prescription to buy Baclofen. However, it is possible to buy Baclofen online without prescription.
History of Baclofen
Originally Baclofen has been developed as a drug to treat epilepsy. It has been first synthesized in Ciba-Geigy in 1962. Despite its low performance for epilepsy treatment, Baclofen had a positive effect on some patients with spasticity. The drug has been initially developed for oral administration, however intrathecal introduction (i.e. drug delivery directly into spinal cord) helps to overcome the difficulties connected with intake of high dosages of the drug. Oral release form of Baclofen caused too many undesirable side effects. There has been recently reported about the efficiency of using Baclofen to treat gastric reflux.
Baclofen reduces excitability of the end sections of afferent sensitive fibers and suppresses intermediate neurons. It results in oppression of nervous impulses transferring. Baclofen helps to decrease the preliminary tension of muscle spindles.
Baclofen reduces clonic seizures and painful spasms in patients with neurologic diseases, which are followed by spasticity of skeletal muscles. The drug increases the volume of movement in joints, thus making it easier to do active and passive kinesitherapy (including massage, manual therapy, and physical exercises).
Baclofen pills are absorbed well in digestive tract. The drug reaches peak concentration in blood within 2-3 hours after its intake. About 30% of used dosage contact plasma proteins.
Baclofen can get through the placental barrier and is released into breast milk. That is why it is strictly contraindicated to use the drug during pregnancy. Breastfeeding women should also avoid taking Baclofen in order not to harm their fetus.
Baclofen molecule collapses completely at the end of its action in a liver and is removed by kidneys.
According to the instruction specified by the manufacturer, Baclofen has a large number of various side effects. Therefore, it is strictly recommended to take Baclofen pills only under strict supervision of the doctor or at least after consultation with your attending physician. It may affect your health condition if you take Baclofen pills without consulting with a medical specialist.
If you suffer from epilepsy and are going to start taking Baclofen, do not stop taking antiepileptic drugs.
You should have regular control your blood test and liver enzymes, as well as sugar levels in blood if you suffer from diabetes or liver disorder.
Besides, it is recommended to avoid activities, demanding concentration of attention and fast reaction, during treatment with Baclofen and its analogs.
What is Baclofen used for?
Baclofen is prescribed to treat:
- increased muscles tone in case of multiple sclerosis;
- cerebrovascular diseases;
- cerebral paralysis;
- spinal cord disorders, including motive motor neurons disease, tumors, myelosyringosis and myelitis
Baclofen can be prescribed for people with increased of muscle tone, which has developed as a result of craniocerebral injury or spinal cord injury.
How to take Baclofen?
Take Baclofen pill with your meal, washing down with enough water or tea. You can divide a pill if needed. Do not take a double dosage of Baclofen in case you missed your dose. Just skip it and wait for the next dosage.
You doctor should determine what dosage is the best for you and long to take Baclofen.
As a rule, adults should take 5 mg of Baclofen at the beginning of treatment three times a day. The dosage is increased up to 20mg of Baclofen a day after 3 days of treatment. In case of need, your may increase further dosage with 3 days interval. Increase Baclofen dosage up to 5mg during each interval. It is recommended to increase dosage more slowly for people with hypersensitivity to Baclofen as well as for people of advanced age.
The final dosage is established so that reduction of muscle tone did not cause a development of excessive myasthenia and did not reduce motor functions.
The average therapeutic dosage of Baclofen is 30-75 mg.
The recommended dosage for people with chronic renal failure is 5 mg of Baclofen a day.
The highest daily dosage of Baclofen for adults is 100 mg.
Children should take 5 mg of Baclofen 3 times a day at the beginning of treatment. The dosage can be gradually increased with an interval of 3 days under strict medical supervision.
The average dosage for children from 3 to 6 years old is 20-30 mg of Baclofen a day.
The average dosage for children from 6 to 10 years old is 30-60 mg of Baclofen a day.
The average dosage of Baclofen for children more than 10 years old is 2,5 mg of the drug on each kg of body weight a day, but no more than 75 mg a day.
You should stop taking Baclofen gradually (it is recommended to decrease Baclofen dosage gradually within 1-2 weeks).
Besides, the drug addiction development is possible, if Baclofen is taken in large dosages.
Baclofen side effects
The following undesirable side effects are usually observed during treatment with Baclofen:
- confusion of consciousness;
- increased fatigue;
- gait disorders;
- tremor of extremities;
- decrease in cardiac output and arterial pressure.
- pain in abdominal area;
- liver function disorder;
- skin rash;
- respiratory depression;
- muscle pain;
- blurred vision;
- accommodation paresis;
- increased perspiration;
- erectile dysfunction;
- decrease in body temperature.
Increased spasticity is possible in some cases, which should be regarded as a paradoxical reaction to Baclofen.
As a rule, side effects are all transient. You should distinguish Baclofen side effects from symptoms of a disease.
Avoid taking Baclofen in case of intolerance to components of the drug (in particular, Baclofen is recommended for people with rare hereditary lactose intolerance).
Avoid using Baclofen to treat epilepsy, seizures (including a tendency to seizures), psychoses, cankers of duodenum and stomach as well as Parkinson's disease.
Baclofen can be used only to treat children more than 3 years old. Use Baclofen for children under 12 years with caution.
Take Baclofen with caution, if you have atherosclerosis of cerebral vessels, cerebrovascular insufficiency as well as chronic kidney failure.
The drug is also used with caution for elderly people.
You should be careful taking the drug if you suffer from diabetes mellitus or liver disorders.
It is not recommended to be engaged in potentially dangerous types of activity during treatment with Baclofen (in connection with a possible decrease in concentration of attention and speed of response).
Can I take Baclofen during pregnancy?
Avoid using Baclofen during pregnancy and breastfeeding, because it may harm your child.
You have to postpone breastfeeding during treatment with Baclofen or to stop taking the drug because Baclofen is released in breast milk.
Baclofen increases an action of medications, oppressing central nervous system as well as alcohol, gout and hypotensive drugs.
Tricyclic antidepressants increase the action of Baclofen in case of simultaneous intake.
There is an increased risk of confusion of consciousness, excitement, and hallucinations if Baclofen is taken together with levodopa and carbidopa.
The following side effects were observed after using Baclofen in high dosages: hypotonia, confusion of consciousness, respiratory depression and coma.
You may experience hypotonia within 72 hours after overdose with Baclofen.
Drink plenty of water and use diuretic drugs in case of Baclofen overdose. However, it is strictly recommended to seek medical help if you have overdose symptoms.
How to buy Baclofen without a prescription?
Buying Baclofen without prescription in your local drugstore is impossible, the drug is not sold over the counter. However, you can buy Baclofen online with no prescription required. Online pharmacy offers you to order Baclofen generic with no RX needed. The cost of Baclofen generic online is much cheaper than in physical drugstore. That is why you can save some money buying Baclofen generic online.