What is Imitrex?
Imitrex (generic Sumatripan) is used to relieve migraine attacks with or without aura, including migraine attacks during women menstrual period.
Imitrex for migraines:
- reduces expanded brain blood vessels (which slows down the process of sensory nerves excitement around vessels and reduces migraine pain).
- prevents a release of neuropeptides, precluding further expanding of brain blood vessels, which also helps to terminate a migraine attack.
As a result:
- The clinical effect is in a total termination of a migraine attack or considerable reduction of a headache. Usually, you may experience the desirable effect in 30 minutes after the drug intake.
- Imitrex is highly effective for about 80% of patients.
- The drug is well tolerated: the majority of side effects are short-term and usually disappear without special treatment.
What is a migraine?
Migraine is one of the most widespread types of a headache known to mankind. Today, migraine is registered at 3-10%, or even according to some specialists, at 30% of the globe population. The peak of migraine attacks is observed at people from 25 to 40 years old (90% of people, suffering from a migraine, had their first attack before 40 years old). Women suffer from a migraine 2-3 times more often than men.
How to get rid of a migraine?
A migraine is characterized by a definite complex of symptoms. Usually, a general practitioner can diagnose a migraine in 95% of cases, making his/her assumption only on clinical assessment of symptoms. Most common symptoms include moderate or strong pulsing headache, usually from one side of a head; nausea and vomiting; intolerance of light (photophobia) and sound (phonophobia); a history of 5 or more attacks with symptoms listed above, duration of each pain attack from 4 to 72 hours (8-12 hours on average).
Up to 20% of people with a migraine may feel unnatural feelings before the attack: blurred vision, sensitivity disorders or other local neurologic symptoms. Such states are called migraine aura. A migraine without aura is observed in approximately 80% of all cases.
The most important migraine feature is that it has a paroxysmal character. Accurately defined attacks are divided by intervals, free from a headache.
What causes migraine headaches?
Despite a long period of intense research of migraine mechanisms, its origins and triggers are unknown. Nevertheless, some pathogenesis links are studied rather well.
It is supposed that migraine attack develops when a certain releaser leads to expansion of meningeal vessels. It stimulates sensory nerve endings surrounding vessels. The activated nerve fibrils, in turn, promote a release of neuropeptides in blood vessels walls.
What is the best migraine medication?
The most efficient migraine treatment is to terminate developing migraine attack as soon as possible. As a rule, the following medications are used for this purpose: analgetics (acetylsalicylic acid, paracetamol), non-steroidal anti-inflammatory drugs (Ibuprofen, Naproxen) and Ergotamine. The treatment efficiency can be increased by using Metoclopramide with these drugs.
The drawback of all these medications for migraine attacks therapy is their efficiency is not constant for all people and for all kinds of attacks. Moreover, most of these drugs may cause serious side effects.
That is why Imitrex is one of the best medicines to cure migraines due its high performance and relative safety for people.
How to use Imitrex generic?
Avoid using Imitrex pills in order to prevent a possible migraine attack.
Take Imitrex pill with a glass of water as soon as possible after the beginning of a migraine attack. The drug is equally effective at each stage of an attack.
Adults should use Imitrex 50 mg (1 pill). In some cases, the dosage can be increased up to 100 mg.
How often can you take Imitrex?
Do not take the second dosage of the drug throughout the same migraine attack if the first dosage of a drug was inefficient. Use Imitrex during subsequent attacks.
If you had a positive effect after the first dosage, but then symptoms renewed, take the second dosage in the next 24 hours. The total daily dosage should not exceed 300mg of Imitrex
Can children take Imitrex?
Imitrex efficiency and safety for children is not yet studied.
Can senior people take Imitrex?
There is a very little experience of using Imitrex for senior people of 65 years and above. Though the drug action is the same for people of all ages, it is not recommended to use Imitrex for people older than 65 years old until additional clinical data is obtained.
What should I know before taking Imitrex?
Take Imitrex pills only if your diagnosis is accurately established as a migraine.
Avoid using Imitrex to treat hemiplegic, basilar and ophthalmoplegic migraine.
You should exclude availability of serious neurologic pathology, other than a migraine, before taking Imitrex.
It should be noted, that people suffering from a migraine may have an increased risk of possible cerebrovascular disorders (the stroke, cerebral circulation disorder).
Some people may experience such transient symptoms as intensive pain or constriction in the chest, which may extend your throat, after using of Imitrex. If such symptoms indicate on heart disease, you should have a cardiological examination.
Avoid taking Imitrex without preliminary survey if you have suspected heart disease. Women in postmenopausal period, men of 40 years and above, as well as people with risk factors for possible coronary heart disease, are in this risk group. However, the medical examination can not always reveal possible heart disorders. Therefore, in some cases, people with serious cardiological complications may have heart troubles after Imitrex intake.
Take Imitrex with caution if you are under supervision concerning hypertension. Some people may have increased blood pressure levels and peripheric vascular resistance after using the drug.
There are reports about exceptional cases of weakness, hyperreflexia and lack of coordination, which were observed after simultaneous intake of selective serotonin reuptake inhibitors (SSRI) and Imitrex. It is recommended to have a preliminary medical examination before taking Imitrex together with SSRI medications if it is clinically justified.
Take Imitrex with caution if you have considerable absorption, metabolism or drug elimination disorders, for example, in case of kidney or liver failure.
You should also be careful when using Imitrex if you have a history of spasms.
You may experience allergic reactions after Imitrex intake if you have hypersensitivity to streptocides. There may be both mild (skin hypersensitivity) and severe (anaphylactic shock) reactions.
Can I take Imitrex during pregnancy?
Avoid taking Imitrex during pregnancy. You should consider the expected advantage for mother in comparison with possible risk for a fetus if it is necessary to take Imitrex.
Can I take Imitrex during breastfeeding?
Try to avoid using Imitrex during breastfeeding. It has been proved that Imitrex is released into breast milk after subcutaneous injection. The drug influence on a child can be minimized if you avoid breastfeeding for 12 hours after Imitrex intake.
Can I drive a car while taking Imitrex?
You can feel drowsiness as a consequence of both migraines and its treatment with Imitrex. Therefore, you should be alert at the wheel or work with other difficult mechanisms with caution, when taking Imitrex.
Side effects of Imitrex
Most common Imitrex side effects include:
- arterial hypotension or a short-term increase of blood pressure;
- short-term pain in a place of injection place;
- feel of warmth;
- pricking, pains, pressure or contraction in various body parts.
Possible Imitrex side effects revealed during post-marketing studies include:
- hypersensitivity reactions, including skin manifestations, and anaphylaxis (very rare);
- a convulsive attack, tremor, dystonia (very rare);
- blurred vision, flashing, diplopia, blindness (usually transient). However, visual disorders may actually be caused by migraine attacks.
- bradycardia, tachycardia, trembling, arrhythmias, coronary vasospasm, stenocardia, myocardial infarction, hypotonia (very rare);
- ischemic colitis, dysphagy, feeling of discomfort in a stomach.
What are Imitrex contraindications?
Avoid taking the drug if you have hypersensitivity to any of its components.
You should also avoid taking Imitrex if you have a myocardial infarction history or having coronary heart disease, stenocardia, diseases of peripheral vessels, or if you have symptoms of coronary heart disease.
It is not recommended to take Imitrex if you have a history of a stroke or a transient ischemic attack.
It is contraindicated to take Imitrex if you suffer from uncontrolled hypertension.
Avoid taking Imitrex if you ha a serious liver failure.
Interaction with other drugs
Avoid using Imitrex together with ergotamine or its derivatives.
It is not recommended to use Imitrex within 2 weeks after you stop taking MAO inhibitors.
There is no information about Imitrex interaction with Propranolol, Flunarizine or alcohol.
There were cases of long term vasospastic reactions Imitrex was used together with Ergotamine. As these side effects can be strengthened by Imitrex, you should have 24 hours interval between Imitrex and Ergotamine intakes. Avoid taking drugs containing Ergotamine withing 6 hours after Imitrex intake.
Avoid using Imitrex together with MAO inhibitors because of their strong interaction.
There were no side effects reported, apart from those listed above, in case of taking up to 400 mg Imitrex a day.
Store the drug in a dry place at room temperature. Keep away of reach of children.
How to buy Imitrex without prescription?
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