What is Maxalt?
Maxalt is a medication used to treat an acute headache (migraine) with or without aura. The analog of the drug (generic Maxalt) is Rizatriptan.
A migraine is a hereditary chronic disease. A person may experience periodic severe headache attacks. In some cases, headache attack is accompanied by aura (symptoms observed shortly before a headache to come), nausea, vomiting.
Frequent migraine attacks considerably deteriorate the quality of life, therefore scientists have long been trying to create drugs, which could relieve a headache quickly and for a long time.
One of the best and most prescribed drugs in the world to treat a migraine is Maxalt with rizatriptan as an active ingredient. The drug selectively stimulates serotonin receptors, which leads to narrowing of blood vessels, decrease in development and release of nervous system protein molecules.
Thanks to this action, molecules do not reach the pain center and headache attack is stopped before starting.
The main Maxalt advantages are:
- Acts in several directions at the same time to stop headache attack.
- Reduces sensitivity to pain.
- Narrows expanded craniocerebral vessels, vessels of brain cover, which reduces pulsation.
- Blocks release of neuromodulators, removing inflammation and pain.
- Provides disappearance of photophobia, vomiting, nausea.
The notable effect comes in 2-4 hours after the drug intake and lasts for several hours.
Treat migraine by yourself only in cases, when the migraine diagnosis is verified by a medical specialist, who have provided you with a treatment plan. Uncontrollable drug intake without prior consultation with a medical specialist may not only cause complications but also influence proper diagnosing of disorders, more serious than a migraine. It may lead to heavy health disorders or even lethal outcome.
Take 10 mg of Maxalt as a single dosage. You can take the second dosage of Maxalt generic if your headache has renewed. The daily dosage of Maxalt is 30 mg with an interval between intakes is not less than 2 hours.
If you also use Propranolol, it is recommended to use Maxalt in a single dosage of 5 mg. Do not exceed your daily dosage of Maxalt 15 mg.
The efficiency of repeated Maxalt intake to relieve a headache during the same migraine attack, if the effect is absent from the initial dose, is not studied during controlled researches.
Avoid using Maxalt if you suffer from:
- hypersensitivity to Rizatriptan or any drug components;
- heavy liver or renal failure;
- history of acute cerebral circulation disorders or cerebral ischemic attacks;
- moderate or heavy arterial hypertension or mild arterial hypertension in the absence of treatment;
- coronary atherosclerosis, including coronary heart disease (stenocardia, history of myocardial infarction or asymptomatic ischemia), signs and symptoms of coronary heart disease, Prinzmetal stenocardia;
- occlusive diseases of peripheral arteries;
Maxalt interaction with other medications
Do not use Maxalt simultaneously with Ergotamine, ergot alkaloid derivatives (including metisergid) or with other 5-HT1B/1D receptors agonists.
It is also recommended to avoid using Maxalt together with MAO inhibitors. Do not take Maxalt within two weeks after termination of MAO inhibitors therapy.
Propranolol can increase a concentration of Rizatriptan in blood.
Take into an account possibility of Maxalt interaction with Timolol and Atenolol.
Simultaneous use of Maxalt with Nadolol or Metoprolol does not lead to undesirable effects.
The drug does not interact with Paroxetine and oral contraceptives.
Maxalt does not influence the efficiency and frequency of possible side effects in case simultaneous use with calcium antagonists, tricyclic antidepressants, propranolol and others β - blockers, valproic acid, opioid analgesics, oral contraceptives, and estrogen.
Using Maxalt together with selective serotonin reuptake inhibitors (SSRIs) can lead to a development of serotonin syndrome (including changed mental state, vegetative nervous system disorders). Such reactions can be very serious.
What should I know before taking Maxalt?
Do not take Maxalt if you have a basilar or a hemiplegic migraine, in a case of a simple headache not typical for a migraine.
Avoid using the drug to relieve adynamy, weakness or a headache. Such a headache can be connected with potentially serious medical conditions (for example, acute cerebral circulation disorders, aneurysm rupture). Narrowing of cerebral vessels can be potentially dangerous in case of these disorders.
Take Maxalt only if you have an established migraine diagnosis.
Maxalt intake may cause transient symptoms, such as chest pain and feeling of chest constraint, which may be rather intensive and extend to a throat. Stop using the drug and consult with your healthcare provider, if such symptoms allow assuming possible coronary heart disease.
Avoid using Maxalt with 5-HT1D-receptors serotonin agonists at the same time.
Consider having cardiovascular system examination before using Maxalt, if you have arterial hypertension, diabetes mellitus, family history of heavy ischemic heart disease as well as in case of smoking.
There is a very limited clinical experience of using Maxalt for elderly people.
Interval of not less than 6 hours is needed between taking generic Maxalt and drugs containing ergotamine.
Safety of Maxalt use in pediatrics is not studied, therefore avoid using the drug for children younger than 18 years old.
Angioedema may develop during Maxalt treatment (for example, face, tongue or throat edema). In case of such side effects, you should be under the supervision of medical specialist before the disappearance of symptoms. Treatment with Maxalt should be immediately terminated. The drug should be replaced with another, which belongs to other class of active ingredients.
Long time use of any headache painkillers can provoke its aggravation. Terminate Maxalt intake and visit your doctor, if you have frequent headaches, probably caused by excessive use of the drug.
Can I drive a car during taking Maxalt?
Maxalt may cause drowsiness in some cases. Cases of dizziness were also reported during the drug intake. That is why you should be alert at the wheel or work with potentially dangerous equipment with caution during migraine attacks or during Maxalt therapy.
Can I take Maxalt during pregnancy and breastfeeding?
There were no thorough studies in terms of safety of using Maxalt during pregnancy. That is why Maxalt intake during pregnancy is possible only in cases of emergency.
You should also avoid using Maxalt during breastfeeding because there is no sufficient information, whether the drug is released in breast milk or not. You should postpone feeding by breast if you need to have treatment with Maxalt.
Maxalt side effects
Clinical effect of Maxalt and its side effects were estimated during controlled one-year clinical studies with more than 3600 people. Dizziness, drowsiness and adynamy/weakness were the most widespread side effects during clinical trials. Other most common side effects of Maxalt include:
- hypersensitivity to drug's components;
- anaphylactic / anaphylactoid reactions;
- taste disorders;
- serotonin syndrome;
- blurred vision;
- ischemia or myocardial infarction;
- acute cerebral circulation disorder. The majority of these adverse reactions were observed at patients having risk factors for possible coronary atherosclerosis.
- blood flush;
- arterial hypertension;
- ischemia of peripheral vessels;
- pharyngeal discomfort;
- goose breathing;
- dry mouth;
- a feeling of thirst;
- excessive perspiration;
- toxic epidermal necrolysis;
- neck pain;
- feeling of tension;
- muscular weakness;
- face pain;
- pain in abdominal cavity or thorax.
How can I buy Maxalt over the counter?
You cannot buy Maxalt over the counter in you local pharmacy. However, you can easily buy Maxalt online without prescription from numerous pharmacies around the web. Order cheap generic Maxalt online with no need to visit your doctor to get a prescription.