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What is Oxybutynin chloride and what it is used for?

generic oxybutyninOxybutynin is a spasmolytic (or antispasmodic) drug (smooth muscle relaxant), used to reduce muscle spasms of the urinary tract and the bladder.

Oxybutynin is prescribed to treat urine incontinence, overactive bladder symptoms (frequent and urgent urination) and pollakiuria (increased daily urination frequency) in cases of the neurogenic instability of bladder function or as a result of the idiopathic instability of detrusor function.

The drug is also used to treat night enuresis (involuntary urination) in children (from 5 years old and older).

What does Oxybutynin do?

Oxybutynin blocks m-choline receptors. It reduces tone and eliminates spasms of smooth muscles of the digestive tract, uterus, urine tract and bile duct. Oxybutynin is especially efficient to reduce spasms of bladder smooth muscles.

In case of neurogenic bladder, Oxybutynin increases its capacity, relaxes detrusor and reduces the frequency of its contractions, reduces the number of urination, including involuntary, and limits urges.

Oxybutynin is well tolerated in case of long-term use (from 1 month to 2 years).

The drug is quickly absorbed through the digestive tract after intake. The maximum concentration of the active component is reached in 45 minutes, depending on the used dosage. The maximum effect is observed within 3 - 4 hours after intake. The residual drug action may be observed for more than 10 hours. In 8 days of oral administration of the drug, an equilibrium concentration is reached.

Oxybutynin is probably not accumulated in elderly people leading active lifestyle and parameters of its action does not differ from those of other adult people.

The drug is metabolized by the liver. Its metabolites can also block m-choline receptors. Oxybutynin is generally released by kidneys.

Oxybutynin dosage

Take Oxybutynin pill before your meals with a glass of water. Dosages and the way of intake are prescribed individually, depending on your disorder, age and health condition.

The adults should usually take Oxybutynin 5 mg 2 - 3 times (no more than 4 times) a day with a maximum dosage of 20 mg.

Children more than 5 years old should usually take Oxybutynin 5mg 2 times (no more than 3 times) a day with a maximum daily dosage of 15 mg.

In case of night enuresis, take the last dosage before going to bed at night.

The elimination half-life of the drug can be increased in advanced aged people. Therefore, it is recommended to begin treatment with a dosage of Oxybutynin 2,5 mg 2 times a day. It can be increased to minimum effective dosage, which provides the positive clinical effect. Usually, the sufficient dosage is Oxybutynin 5 mg twice a day (at least for people with a small body weight).

The initial dosage for children of 5 years and older is Oxybutynin 2,5 mg 3 times per day. The dosage can be increased, if necessary, to get a satisfactory clinical effect. The recommended dosage for children is from 0,3 to 0,4 mg/kg of body weight a day.

Avoid using Oxybutynin for children under 5 years old.

What should I know before taking Oxybutynin?

It is necessary to review the expediency of treatment with Oxybutynin each 4-6 weeks, as bladder function can already be normal in some people.

The drug will not be efficient to treat stressful urine incontinence.

Elderly people, who can be more sensitive to Oxybutynin effects, as well as people with neurocirculatory dystonia, hernia of diaphragm esophageal opening or other serious digestive tract disorders, liver and kidney disorders, tachyarrhythmia or cerebral circulation insufficiency, should take the drug with caution.

Using Oxybutynin may be a reason for a strengthening of clinical manifestations of hyperthyroidism, heart disorders, arrhythmias, tachycardias, chronic heart failure and prostate hyperplasia.

Long time use of Oxybutynin can cause discomfort of oral cavity because of the insufficient salivation, which can provoke teeth caries, periodontoclasia or candidiasis of oral mucosa.

Antibacterial therapy should be prescribed in case of the urinary tract infection.

Avoid using the drug if you have a hereditary intolerance to galactose, malabsorption of glucose or lactase insufficiency because Oxybutynin contains lactose.

The drug may cause some visual disorders and drowsiness. That is why consider avoid driving a car or working with potentially dangerous mechanism during treatment.

Contraindications to use

Avoid using Oxybutynin if you have:

  • hypersensitivity to the drug's components;
  • obstructive digestive tract disorders;
  • glaucoma;
  • expansion of colon (including toxic, complicated by ulcer colitis);
  • myasthenia (including myasthenia gravis);
  • paralytic Ilheus;
  • heavy colitis;
  • intestines atony at debilitated and elderly people;
  • obstructive uropathy;
  • acute bleedings in case of blood circulatory system instability;

People with hyperthermia in case high-temperature environment, breastfeeding and pregnant women, as well as children under 5 years old, should also avoid using Oxybutynin.

Take Oxybutynin with caution if you have:

  • neurocirculatory dystonia;
  • pathology of kidneys and liver;
  • hyperthyroidism;
  • coronary heart disease;
  • congestive heart failure;
  • arrhythmia;
  • tachycardia;
  • arterial hypertension;
  • benign prostate hyperplasia (especially at initial stages);
  • nonspecific ulcer colitis;
  • a phrenic hernia (including connected with gastroesophageal reflux);
  • diarrhea;
  • incomplete intestinal obstruction.

Elderly people should also take the drug with caution and under the supervision of an attending physician.

Can I use Oxybutynin during pregnancy and breastfeeding?

The safety of Oxybutynin use during pregnancy is not established. It was revealed during researches on animals that use of Oxybutynin in dosage, which had a toxic effect on mother's body, caused reproductive toxicity. That is why avoid using the drug during pregnancy.

You should also stop breastfeeding during treatment with Oxybutynin, as the drug is released with breast milk.

Oxybutynin side effects

Using Oxybutynin may cause the following possible side effects:

  • drug mouth;
  • constipation;
  • nausea;
  • meteorism;
  • vomiting;
  • decreased intestines and stomach motility of intestines and stomach;
  • stomach discomfort;
  • gastroesophageal reflux;
  • loss of appetite;
  • diarrhea;
  • urination disorders (including urinary retention);
  • lactation suppression;
  • erectile dysfunction;
  • tachycardia;
  • heartbeat;
  • vasodilation;
  • arrhythmia;
  • blood flush (more expressed in children);
  • dizziness;
  • weakness;
  • sleeplessness or drowsiness;
  • nightmares;
  • headache;
  • hallucinations;
  • spasms;
  • excitement;
  • cognitive disorders (disorientation, confusion of consciousness, paranoia, delirium);
  • an increase of intraocular pressure;
  • closed-angle glaucoma;
  • blurred vision;
  • mydriasis;
  • accommodation paralysis;
  • decreased sweating;
  • allergic reactions (rash, hives, photosensitization, angioedema).

Oxybutynin interaction with other drugs

Sedatives and alcohol increase drowsiness and dizziness during Oxybutynin therapy.

Avoid using Oxybutynin together with anticholinergic drugs.

There are reports of Oxybutynin interaction with anticholinergic drugs, Amantadine, Phenothiazine, Butorphanol, tricyclic antidepressants in case of their simultaneous intake. Thus, you should be cautious taking these drugs together.

Oxybutynin can influence the absorption of other drugs due to a decrease of digestive tract motility.

Overdose with Oxybutynin

You may experience a strengthening of side effects expressiveness and emergence of atropine intoxication symptoms, such as pupils expansion, sharp decrease of secrets selection, smooth muscles paralysis) in case of Oxybutynin overdose.

If you experience adverse reaction listed above, call the ambulance immediately.


Store the drug in a dry place at room temperature.

Where to buy Oxybutynin generic?

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