What is Tylenol?
Tylenol is a drug used to relieve pain, treat fever and remove symptoms of allergy, cold, cough and the flu. An active ingredient of original formula is acetaminophen, which is an analgesic and antipyretic remedy. The drug is known under the generic name of Paracetamol worldwide. Tylenol trade mark is a property of McNeil Consumer Healthcare company, the department of Johnson & Johnson corporation.
Tylenol impacts on the thermal and pain control centers. The main active ingredient in Tylenol is acetaminophen. The drug has no negative impact on water-salt metabolism and mucous membranes of the gastrointestinal tract.
Tylenol is produced in a liquid form, which is intended for adult patients. Tylenol for children is marketed in a form of powder for making a liquid solution. Besides, the drug is produced as an infusion solution, in the form of capsules, rectal suppositories, and suspension.
How To Take Tylenol?
Tylenol is effective to treat fever caused by infections. It also helps to soothe a toothache, headache, and also pains caused by arthralgia, migraine, myalgia, which are the result of dysmenorrhea.
Take Tylenol 1-2 hours after your meals.
It is strongly advised to take a lower dosage of the drug if you have Gilbert's syndrome, liver and kidneys disorders. Patients with disorders listed above as well as older people should have an increased break between Tylenol intake.
Take Tylenol suspension 4 times a day. You can take the drug for 3 days to deal with fever and for 5 days to reduce pain without attending your physician. If fever or pain symptoms are still present, it is strongly advised to visit your doctor.
Adult Tylenol Dosage
Adult patients and children starting from 12 years, whose weight exceeds 40 kg (88 lbs), should take 500 mg of Tylenol 4 times a day for 5-7 days.
The dosage of Tylenol rectal suppositories for adults is 500 mg. It is not recommended to use them more than 4 times a day.
Children Tylenol Dosage
The dosage for children under 3 years with a weight under 15 kg is 750 mg.
For children under 6 years with a weight under 22 kg is 1000 mg.
For children under 9 years with a weight under 30 kg is 1500 mg.
For children under 12 years is 2000 mg.
The dosage of Tylenol in the form of suspension for 6-12 years old children is 10-20 ml.
The dosage for 1-6 years old children is 5-10 ml of suspension.
The dosage of Tylenol rectal suppositories for 12 - 15 years old children is 250-300 mg 4 times a day.
For 6 -12 years old children is 250-300 mg 3 times a day.
For 6 - 8 years old children is 200-250 mg 3 times a day.
For 4 - 6 years old children is 150 mg 3 times a day.
For 2 - 4 years old children is 150 - 200 mg 2 times a day.
Infant Tylenol Dosage
The dosage for babies under half a year with a weight under 7 kg is 350 mg.
The dosage for babies under one year with a weight under 10 kg is 500 mg.
The dosage of suspension for 3 - 12 months babies is 2.5-5 ml of suspension.
The suspension dosage for infants under 3 months is prescribed individually by your pediatrician.
The dosage of Tylenol rectal suppositories for 1 - 2 years old children is 80 mg not more than 4 times a day.
For 6 - 12-month infants is 80 mg, not more than 3 times a day.
For 3 - 6-month infants is 80 mg 2 times a day.
Tylenol with Codeine
Tylenol is a drug prescribed for pain relief, allergy and treatment of the symptoms connected with cold and flu. Other drugs to treat allergy and cold include dextromethorphan, antihistamines and expectorants. Tylenol is also marketed as a strong anesthetic drug containing codeine known as co-codamol:
Tylenol #1 contains 325 mg of aсetaminophen and 8 mg of codeine;
Tylenol #2 (300 mg / 15 mg)
Tylenol #3 (300 mg / 30 mg)
Tylenol #4 (300 mg / 60 mg)
In Canada, Tylenol #1, #2 and #3 include 15 mg of caffeine, in addition to other ingredients. Besides, you can buy Tylenol #1 without prescription in Canada. Other forms of Tylenol containing codeine require a prescription. Acetaminophen is also a component of other narcotic analgesics, such as Percocet, which also contains oxycodone. Lortab and Vicodin also contain Acetaminophen in addition to hydrocodone.
Tylenol with Codeine Dosage
Tylenol with Codeine dosage depends on your health condition and severity of pain. Take 15 to 60 mg of codeine (not more than 360 mg a day) and 300 to 1000 mg of Acetaminophen ( not more than 4000 mg a day). The interval between intakes is 4 hours or more.
Tylenol Side Effects
Tylenol may cause the following side effects as erythema, skin rash, angioedema, nausea, dizziness, pain in the epigastric area, excitement, cyanosis, anemia, short wind, agranulocytosis, heartache, leukopenia, thrombocytopenia and neutropenia.
If Tylenol is taken in rather high doses, it may cause renal pain, interstitial nephrite as well as papillary necrosis.
Avoid taking Tylenol if you have allergic reactions to its components. Do not give Tylenol to infants under one month.
Take the drug with caution if you suffer liver or renal failure, viral hepatitis, benign hyperbilirubinemia and diabetes. People suffering from alcoholism, older people, pregnant and breastfeeding women should also take Tylenol with caution.
According to Tylenol instruction, the drug can become a reason of decrease in efficiency of uric acid removal medicines. Ethanol can provoke the development of acute pancreatitis.
History of Tylenol
The American gastroenterologist James Roth recommended paracetamol as an alternative to aspirin safe for a stomach. Dr Roth was also the chief consultant of the McNeil Laboratories company. In 1953 McNeil Laboratories has provided Algoson drug on the market, containing paracetamol and sedative butabarbital sodium. In 1955 McNeil Laboratories presented Tylenol Elixir for children, containing paracetamol as the only active ingredient. Originally drug was intended for children, however, Tylenol Elixir has won all the market of anesthetics in the US very soon. The following forms of Tylenol are available on the market today: extra (500 mg of paracetamol), for children, long action and hypnagogue. The new form of the drug, Tylenol Ultra, was presented in 2005 in Canada containing 500 mg of paracetamol and 65 mg of caffeine.
Tylenol and suicides
On September 29, 1982, the series of suicides, called afterward "Tylenol's Horror" has begun. This day the first seven members of suicide group have committed suicide in Chicago subway, having swallowed Tylenol Extra together with cyanide. Within a week this group has redeemed 31 million packs of pills. This purchase is one of the first largest purchases for all history of the development of pharmaceutical industry in the USA. After that incident, all Tylenol pill packs have been removed from the market. The consultant Martin Kohl and the manager of the Calle & Company company employed by the president of McNeil Joseph Chiza have decided to release capsules in gelatinous cover under the name "Tylenol Gelcaps" that had to recover 92% of losses of the company. Capsules were on sale in just 10 weeks after the prohibition. The crisis cost the company more than 100 million dollars, however, Tylenol has managed to win back 100% of the market share, which it had before the crisis. Tylenol remains the leader of sales and controls about 35% of anesthetics market in North America, according to the research published in 2003.
Tylenol recall from the market in 2010
On January 15, 2010, in 20 months after receiving the first complaints from consumers, Johnson & Johnson declared the recall of several hundred consignments of popular medical drugs, including Benadryl, Motrin, Rolaids, Simply Sleep, St. Joseph Aspirin and Tylenol. The response has been mediated by complaints about musty smell which, allegedly, was a result of chemical pollution with 2,4,6-tribromoanizol. It is not known of 2,4,6-tribromoanizol impact on health, however, there are no reports of serious side effects in medical literature.
According to FDA data, the response has followed in 20 weeks after the McNeil company has for the first time started investigating complaints of consumers about Tylenol Arthritis Relief packs smell. About 53 million vials of the drugs marketed without prescription, including Tylenol, Motrin and Rolaids, Benadryl and St were subject to withdrawal. The new recall for over 40 products, including liquid anesthetics for children and babies, Tylenol, Motrhin, Zyrtec and Benadryl, has followed on 30 of April, 2010. The FDA report states that experts have found thick dust layer and dirt on the central equipment, hole in a ceiling and other violations. On Wednesday, May 5, 2010, FDA has confirmed that it was Burkholderia cepacia bacterium to be found in Johnson & Johnson. The authorities have declared that Burkholderia cepacia seldom causes heart troubles in people with healthy immune system, however, patients with weak immunity and with chronic diseases of lungs, such as cystic fibrosis, can be more subject to the risk of infection.
Tylenol PM is a trade mark of acetaminophen (paracetamol) and diphenhydramine mix medicine. The drug is sold by the Johnson & Johnson company as a combined analgesic and the sedative, which doesn't cause allergy. Diphenhydramine is an anticholinergic, which is as active ingredient part of Benadryl (antihistamine) and Benidril, cough remedy and cold.
Is It Safe To Take Tylenol While Pregnant?
Women, who is going to use the drug, may reasonably ask: "Can I take Tylenol while pregnant?". Actually, there were very few instances of Tylenol overdose during pregnancy. Thus, pregnant and breastfeeding women can safely take Acetaminophen for short periods of time according to the doctor's instructions. It can be used for pain relief and fever on all pregnancy stages.
Tylenol Overdose Risk
There are several reports in the medical literature about risks connected with acetaminophen intake, especially in combination with alcohol (though not always connected specifically with Tylenol). In Septemper 2013 This American Life tv show and ProPublica articles have been reported of such risks. In This American Life broadcast, it was reported that "acetaminophen, an active ingredient of Tylenol, is connected with the greatest number of death (among the drugs which you can buy without a prescription), according to the data obtained from the federal government. More than 150 Americans die every year". This information contradicts data in medical literature which show that the most widespread alternative to acetaminophen, non-steroidal anti-inflammatory drugs (including Naproxenum, the Ibuprofen and Aspirin) cause 3200 death and 32000 hospitalizations annually, and only as a result of gastric bleedings. ProPublica has reported that FDA is familiar with studies showing risks of acetaminophen for a long time.
The Tylenol manufacturer, McNeil Consumer Healthcare, the division of Johnson & Johnson, repeatedly rejected the need for safety warnings availability restrictions of dose and other measures important for the safety of users". It includes warnings of liver injuries and of acetaminophen use in combination with alcohol.
Tylenol has numerous advertising campaigns. In one of them the drug is positioned as the means, "restoring to normal life", and in another, the emphasis on slogan is given: "Feel better Tylenol". In the second advertising campaign, the focus is set on an importance of sleeping. In this commercial, the great number of the sleeping people is shown, and the voice-over explains how the dream can revitalize the body.
In other advertising, an emphasis is placed on a return of users to normal life. Various people feeling headaches and other types of pains are shown, and the voice-over broadcasts that Tylenol Rapid Release can help to get rid of pain.
In an old commercial of 1986, the emphasis is put on that most hospitals across the country trust Tylenol. In this commercial, the actress Susan Sullivan tells buyers that Tylenol is a drug, which Americans can trust because the great number of doctors also trust Tylenol. The actress also reports that doctors prescribe Tylenol #4 times more often than all other painkiller drugs combined.