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The best over the counter pain medication

buy painkiller drugs onlinePain is an integral part of our life. It is a specific defense reaction in response to a stimulation of pain receptors in various body parts and tissues. The emergence of pain points to malfunctions, serious diseases and pathological disorders in our body. It specifies threat to our health and helps to reveal and fix the problem. Pain is an alarm signal, which cannot be ignored.

However, pain has not only positive but also negative qualities. Pulsing, acute, nagging pain - all these unpleasant feelings are breaking our usual mode of life. Each of us having hardly felt pain, tries to eliminate it as soon as possible. But how to get rid of the pain? How to relieve pain, which can have different character and intensity? Unfortunately, it is often impossible to do it without strong pain pills. Pain medication (or painkillers) are a group of drugs, which relieve pain. Depending on the main active ingredient and release forms, they can influence the peripheral nervous system, brain or to have a topical analgesic effect.

Very important! Pain relievers do not treat diseases! You may have already heard that such drugs only relieve pain feelings, without influencing pain origin. In other words, you can temporarily get rid of unpleasant feelings with a help of painkillers. The disease or another pathological process will progress further in the absence of treatment, aggravating pain attacks. Therefore, it is very important to seek medical help in case of constants and severe pains.

There are a lot of various pain relievers on the market. You can buy pain pills over the counter or purchase the strongest pain medication by a prescription only.

OTC pain drugs are simple non-narcotic painkillers, which are used to relieve moderate pain and reduce inflammation.

The best and the strongest pain medications are opioid or synthesized narcotic substances, which are very efficient to get rid of the acute pain.

Over the counter pain medications as well as prescription pain drugs can be used to treat various types of pains, such as lower back pain, neck, tooth pain, nerve pain, joint, arthritis pain etc.

The main pain medication groups are paracetamol (also known as Acetaminophen), non-steroidal anti-inflammatory drugs (NSAIDs), such as Voltaren, Diclofenac, Ibuprofen, Motrin, Mobic etc, and opioid painkillers (morphine, oxycodone).

Types of painkillers

The list of pain medications can be divided into two groups:

OTC pain medication

First group. Non-narcotic pain medication, such as NSAIDs and paracetamol. The main advantage of these drugs is that they do not influence nervous system strongly. Besides, having analgesic effects, NSAIDs are capable of eliminating an inflammation thanks to their structure.

Prescription painkillers

Second group. Narcotic drugs, such as opioid pain pills. The main feature of the opioid painkillers is an immediate effect on the central nervous system. They change the feeling of pain, turning discomfort into a sense of euphoria, pleasure, etc. Opioid drugs only influence on receptors. Everything else (feelings, temperature, sensations) remain the same. Thus, a person can lead a quite normal life, but in a little-detached state. Because of this impact on the cerebral cortex, a person gradually gets used to opioid drugs, especially if he or she uses them for a long time.

Only a medical specialist can prescribe the drug, which is suitable for you, depending on your disease and health condition. So, before prescribing any narcotic painkiller, which of course is much stronger and more effective than non-narcotic one, the doctor has to weigh all pros and cons, assess the situation as well as advantages and possible side effects.

Muscle relaxers

Muscle relaxers is a closely related to painkillers group of medications. These drugs cannot be classified into any of pain medication groups mentioned above, as they are neither narcotic drugs nor simple pain relievers.

The main goal of muscle relaxants is to eliminate spasms of muscles, digestive tract, urogenital system etc.

Spasms can result from improper meals (especially digestive tract spasms), any chronic diseases as well as to be a result of excessive physical exercise stresses.

Sometimes it is more reasonable to buy muscle relaxers than painkiller pills because spasm can be a pain trigger. The best and strongest OTC muscle relaxers are Baclofen, Zanaflex, Robaxin (Methocarbamol).

Paracetamol and NSAIDs

Tha exact mechanism of Paracetamol (Acetaminophen) is not defined. Apparently, it acts directly on the brain, not on the periphery in nerve endings. Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenases, which leads to a reduction of prostaglandins. Unlike paracetamol and synthetic narcotic drugs, it reduces not only pain but also inflammation.

Paracetamol has few side effects and is considered safe in general. Though, a large dosage and a long- time intake may lead to potentially life-threatening injuries to a liver and kidneys. Usual Paracetamol release forms are oral pills and rectal suppositories. However, Paracetamol for intravenous administration was put on the market in 2002 and is considered more efficient to relieve pain.

Most common possible side effects of NSAIDs are peptic ulcer, renal failure, allergic reactions, the risk of bleeding.

COX-2 inhibitor drugs

These drugs are modified NSAIDs. These drugs (for example, Rofecoxib and Celecoxib) are equally effective pain relievers in comparison with NSAIDs but have less risk of gastrointestinal bleedings.

However, it was revealed that the majority of COX-2 inhibitors increase a risk of cardiovascular diseases. It has led to the withdrawal of some drugs from the market.

Narcotic painkillers

Morphine as well as other substances, like codeine, oxycodone, have a similar impact on a brain system of opioid receptors. Buprenorphine is believed to be a partial agonist of opioid receptors, and Tramadol - an opiate agonist with SNRI properties (norepinephrine reuptake inhibitor). Tramadol is structurally closer to Venlafaxine than to codeine. It provides the not only opioid-like pain relief effect, but also acts, as weak, but high-speed substance, for serotonin release and as norepinephrine reuptake inhibitor.

The effects of serotonin and norepinephrine on pain are not completely understood. However, they have established causal relationships. That is why SNRI drugs are efficient to relieve pain in combination with opioid meds. Opioids dosages can be limited to opioid toxicity (confusion of consciousness, respiratory depression, myoclonic spasms and miotic pupils), spasms (Tramadol).

Though narcotic medications are by far the strongest pain medications, they can have some unpleasant side effects. Nausea, vomiting, itch are common side effects during treatment with morphine. Almost all people, taking morphine, suffer from constipation.

Narcotic painkiller pills are safe and effective pain relievers if taken properly. However, opioid drugs cause addiction, if they are used in large dosages and for a long period of time. The addiction effect means that the frequent use of a drug can lead to a weakening of its effect. Thus, you may need to increase its dosage to maintain its efficiency. Addiction is a subject of special concern of people, suffering from chronic pain.

Other non-narcotic pain medication you can buy OTC

There are other types of pain medications, which are effective for patients with chronic or neuropathic pain. Tricyclic antidepressants are known to relieve pain in some cases. Nefopam was used to relieve pain together with opioids. Anticonvulsant drugs are the most often used for neuropathic pain as their mechanism of action suppresses a feeling of pain.

Over the counter pain medications used in combinations

Pain medications are often used in combinations in various over the counter painkillers, for example with paracetamol and codeine. They can also be found in combination with vasoconstrictor drugs, such as antihistaminic drugs to treat allergy.

Use of Paracetamol, Aspirin, Naproxen and other NSAIDs along with opioid drugs has positive synergy effect, relieving pain in several places. Nevertheless, some combined pain relievers have shown few advantages of efficiency compared with similar doses of their separate components. Moreover, these combined pain medications can often lead to considerable side effects, including accidental overdose.


Flupirtine is a central action drug, opening potassium channels with weak properties of NMDA receptor antagonist. It is a muscle relaxer used to relieve moderate and severe pain as well as a migraine. It is considered to have no anticholinergic properties and does not influence receptors of dopamine, serotonin or histamine. It does not cause addiction.

Topical analgesic medications

Topical analgesics are recommended in order to avoid unpleasant side effects. You can buy topical analgesics in various release forms, like cream, gel, eye drops, patches, ointment, spray etc. For example, joint pain can be treated with pain relief cream or gel, containing ibuprofen or diclofenac. You can also have injections of Lidocaine and steroids to relieve joint pain.

What is the strongest painkiller? Prescription and over-the-counter.

best painkillersNarcotic analgesic drugs, like Tramadol or Hydrocodone, are the strongest painkillers. You need to have a prescription to buy such pain pills online or at your local pharmacy.

There is a long list of painkillers to choose from, depending on a type of your pain. Some opioid pain meds are long-lasting, relieving a person of strong pain for quite a long time. Other drugs are short-action, reducing seizure type pains for a small period of time. The one thing is common for narcotic analgesics - they all are used in case of acute pain. The most known drugs from this group are Morphine, Methadone, Promedol, Omnopon, Hydrocodone.

Narcotic pain medications have strong analgesic activity. That is why they are used in case of serious damages, injuries and diseases, which are followed by intolerable pains. At the same time, narcotic pain pills have a serious impact on the central nervous system. You may feel euphoria at the beginning of treatment, but long time intake of narcotic meds may lead to mental and physical addiction. Opioids negatively influence the central nervous system, causing hallucinations. Besides, narcotic analgesics can oppress breath, raise the tone of bladder and intestines, cause vomiting, cough, drowsiness.

The strongest pain medications are divided into 3 groups, depending on the chemical / physical structure and properties. Natural alkaloids, which are contained in poppy (Papaver somniferum), belong to the first group. These are well-known Codeine and Morphine.

The second group represents semi-synthetic drugs. Morphine molecule is altered chemically to get such drugs (Ethylmorphine, for example).

The third group is synthetic substances, which have no natural analogs. They are produced by a method of full chemical synthesis (Promedol, Fentanyl, Tramadol, Hydrocodone). Considering properties of these drugs, dangerous to people, and serious side effects, as is strongly recommended not to use of narcotic pain medication without consulting with a medical specialist. You can buy pain pills from the last 2 groups only having a prescription from your doctor.

Non-narcotic analgesics are synthetic drugs, which are available in each first-aid kit at home. They are not so efficient in relieving pain, as opioid painkillers. The most known non-narcotic analgesics are Aspirin, Paracetamol, Analgin, Pyramid and other widely used drugs. These over the counter painkillers are used to treat inflammation of various body parts and tissues, like neuritis, arthritis, toothache and other disorders, which are followed by pain. Besides, these drugs can have febrifugal effect in case of viral diseases or a simple cold.

There are also medicines, which relieve pain but do not belong to any group of analgesics. These are muscle relaxers, which are used to eliminate muscle spasms of internal bodies. Baclofen, Zanaflex, and Methocarbamol are the examples of the best muscle relaxers.

What is the best over the counter pain reliever?

Unfortunately, you need to have a prescription to buy painkiller pills with a strong action. As a rule, they all are opioid or synthetic narcotic drugs and are on a list of controlled substances according to FDA. Aspirin, Acetaminophen, Diclofenac, Ibuprofen and other best over the counter pain medications are not so efficient in relieving acute pain. NSAIDs work better to reduce various inflammations as well as to decrease a body temperature in case of viral infection or cold.

However, you can buy painkiller pills online without prescription. A lot of online pharmacies offers to order strongest pain meds with no RX required.

How to get pain pills?

Can you really buy pain pills online? This question is rather popular among people, who need to buy painkillers without a prescription. There are a lot of situations when you cannot just visit your doctor and get a prescription to order pain medication at your local drugstore. That is why online pharmacies may help in such cases.

For the first, usually, you can buy pain pills online without prescription from an international pharmacy (Canadian, Mexican or some other offshore pharmacy). It is very convenient to purchase painkillers online in just a few clicks without visiting your doctor.

Secondly, the cost of pain pills online is cheaper than in your local pharmacy, because you can order generic medication. Generics are 100% analogs of the brand medication but cost several times cheaper. Buying generic drugs may save you some money.

Usually, you may even buy painkillers online with overnight delivery, which is very important when you need to relieve acute pain.

And only online pharmacies offer pain pills for sale, providing great discounts. All you have to do is to choose trusted online pharmacy with a lot of positive feedbacks in order to avoid fake drugs.